Asthma patients less likely to develop brain tumours: Washington University researchers

Researchers at Washington University School of Medicine in St. Louis have discovered that people who have been diagnosed with asthma are less likely to develop brain tumors than others. The research, published in the Nature Communications Journal, suggests that a type of immune cell known as “T cells” that help with asthma helps prevent the growth of brain tumors.

This was found after a new study in a mouse by researchers at the university in which T cells were observed to behave in a way that causes lung inflammation but also helped prevent the growth of tumors, suggesting that what may be harmful to the lungs could be good news for the brain.

Speaking about the same, senior author David H Gutmann, Ph.D., and Donald O. Schnuck Family Professor of Neurology, said T-cell reprogramming in patients with brain tumors could help treat such conditions. “Of course, we’re not going to start triggering anyone’s asthma,” he added. Gottman also talked about the medical intervention that can be taken to treat a brain tumor, Gottman said, What if we could manipulate the T cells in order to think that they required substances when they entered the brain so that there is no support for brain tumor formation and growth. Find cotton in your type of treatments that target T cells and their interactions with cells in the brain.

The idea of ​​inflammatory diseases of brain tumors was proposed 15 years ago: a study

According to research published in the journal, the idea of ​​inflammatory diseases including asthma and eczema affecting the development of brain tumors was proposed 15 years ago on the basis of epidemiological observations. However, scientists have not been able to find any reasons for the association and association of both diseases.

Similarly, Gottman, director of the University of Washington’s NF Center, noted the connection between the two as well, revealing the critical role of immune cells in his recent studies. As part of this, postdoctoral researcher Jit Chatterjee who is also the paper’s first author took on the challenge of investigating the association.

studied mice transgenic for a mutation in the NF1 gene by forming gliomas in the optic pathway at 3 months of age. He then exposed these mice to irritants that cause asthma and subsequently treated a control group with saline for comparison.

At the age of 6 months, it was observed that mice with asthma did not form brain tumors. The mice also secreted a protein called decorin, which is useful for the brain.

Photo: shutterstock

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