Aspirin use linked with increased risk of heart failure: Study

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Aspirin use was associated with an increased risk of heart failure: a study & nbsp | & nbsp Image source: & nbspiStock Images

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Brussels: According to new research, taking aspirin is associated with a 26% increased risk of heart failure. Other factors associated with it are smoking, obesity, high blood pressure, high cholesterol, diabetes and cardiovascular disease. The results of this research have been published in the ESC Heart Failure Journal.

Said study author Dr. Blerim Mujage from the University of Freiburg, Germany.

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“Although the findings require confirmation, they do suggest that the potential link between aspirin and heart failure needs to be clarified,” Mujaj added.

The effect of aspirin on heart failure is controversial. This study aimed to evaluate its relationship to the incidence of heart failure in people with and without heart disease and to assess whether drug use is associated with a diagnosis of new heart failure in people at risk.

The analysis included 30,827 people at high risk of heart failure who were enrolled from Western Europe and the United States in the HOMAGE study. ‘At risk’ was defined as one or more of the following: smoking, obesity, high blood pressure, high cholesterol, diabetes and cardiovascular disease. Participants were 40 years of age and older and free of heart failure at baseline. Aspirin use was recorded at enrollment and participants were classified as users or non-users. Participants were followed up for the first occurrence of fatal or nonfatal heart failure requiring hospitalization.

The average age of the participants was 67 years, and 34 percent were women. At baseline, a total of 7,698 participants (25 percent) were taking aspirin. During the 5.3-year follow-up period, 1,330 participants developed heart failure.

The investigators evaluated the relationship between aspirin use and incident heart failure after adjusting for gender, age, body mass index, smoking, alcohol use, blood pressure, heart rate, blood cholesterol, creatinine, hypertension, diabetes, cardiovascular disease, renin-angiotensin-aldosterone system inhibitors, calcium channel blockers, and diuretics. Urine, beta-blockers, and lipid-lowering drugs. Taking aspirin was independently associated with a 26 percent increased risk of heart failure.

To check the consistency of the results, the researchers repeated the analysis after matching aspirin users with nonusers for heart failure risk factors. In this matching analysis, aspirin was associated with a 26 percent increased risk of a new heart failure diagnosis. To verify the results further, the analysis was repeated after excluding patients with a history of cardiovascular disease. In 22,690 participants (74 percent) free of cardiovascular disease, aspirin use was associated with a 27 percent increased risk of heart failure.

Dr. Mujaj said: “This was the first large study looking at the relationship between aspirin use and heart failure in individuals with or without heart disease and at least one risk factor. Aspirin is commonly used – in our study one in four participants was taking the drug. In these In the population, aspirin use was associated with symptomatic heart failure, regardless of other risk factors.

He concluded, “Large, multinational, randomized trials in adults at risk for heart failure are needed to verify these findings. Until then, our observations suggest that caution should be exercised when prescribing aspirin to those with heart failure or those with risk factors for this condition.” “

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